The hottest near infrared fluorescence imaging is

2022-08-18
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Near infrared fluorescence imaging is developing rapidly. Shenzhen Advanced Institute expands the spectral range of near infrared fluorescence imaging

near infrared spectroscopy technology can not only analyze the shape and absorption peak of the spectrum, but also calculate the broadband reflectance of the spectrum, which can be compared with other data sets

recently, cailintao team of Shenzhen Institute of advanced technology, Chinese Academy of Sciences found that a class of molecular dyes have different fluorescence emission peaks in nir-1a and nir-1b regions, and proved the feasibility and superiority of NIR IB region near-infrared fluorescence imaging through plant broccoli vein and animal brain glioma models. The relevant research results were published on theranostics under the title of near infrared fluorescence imaging in the largely unexplored window of 900 – 1000 nm

the wavelengths of near-infrared fluorescence imaging are mainly concentrated in the nm band (nir-1a) and the 1,700 nm band (nir-ii), which have low spontaneous fluorescence, low scattering rate and weak biological tissue absorption. In recent years, despite the rapid development of near-infrared fluorescence imaging, scientists pay little attention to near-infrared fluorescence imaging in nm (nir-1b) region. On the one hand, there is a water absorption peak in nir-ib region, which scientists believe will affect the quality of near-infrared fluorescence imaging in this band. On the other hand, there are almost no molecular probes with fluorescence emission peaks in nir-1b region

the waves of near infrared fluorescence are mainly, such as the incentive policies for the transformation of scientific and technological achievements, concentrated in nm band (nir-1a) and nm band (nir-ii), which have low spontaneous fluorescence, small scattering rate and weak biological tension absorption In recent years, the relevant national departments of near I once again organized the revision of the national standard of polyurethane waterproof coating. 5. Controller: controller failure revision nfrared fluorescence imaging has developed rapidly, but scientists rarely pay attention to near infrared fluorescence imaging in the nm (nir-1b) region One aspect is that there is a water absorption peak in the NIR-Ib region. Scientists think i14.. Host size: 430*315*855mmt will affect the quality of near infrared fluorescence imaging in this band, on the other hand, it is almost not at present A molecular probe for the fluorescence emission peak of the NIR-1b region.

in this study, researchers evaluated the performance of NIR IB region near-infrared fluorescence imaging through leaf vein imaging of plants and brain glioma imaging experiments of animals. The results showed that nir-1b region near-infrared fluorescence imaging could produce clearer leaf vein and brain glioma images than NIR ia region near-infrared fluorescence imaging. In addition, the researchers designed simulation experiments of plant leaves and animal muscle tissue, and analyzed them by linear spectral separation method. It was found that spontaneous fluorescence, scattering rate and light absorption of biological tissue in nir-1b region were reduced, indicating that nir-1b region near-infrared fluorescence imaging has certain advantages. These findings broaden the spectral range of near-infrared fluorescence imaging and are of great significance to biomedical research

the research work has been supported by the National Natural Science Foundation of China, the research team of Guangdong Natural Science Foundation, Guangdong Key Laboratory of nano medicine and basic research of Shenzhen Science and technology innovation Commission. Cai Lintao and Gong Ping, researchers of Shenzhen Institute of Advanced Sciences, are the co correspondents of the paper, and Deng Guanjun, a member of the research group, is the first author of the paper

heptamethine cyanine dye molecular probe has different fluorescence emission peaks in nir-1a and nir-1b regions, and its application in vein imaging of green pineapple

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